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Elizabeth Taylor denies she’s getting married again

By admin
for Better World Eevents

Published: April 12, 2010

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Elizabeth Taylor posted a message on Twitter Monday denying rumors she is engaged to her manager.

tradeon Thursday and was around 91.00 yen JPY= in Asia trade.Investors welcome a softer yen as it boosts exporters’ overseasprofits when repatriated. A study conducted by Public Health — Seattle & KingCounty found that stores with attached gas stations are most likely to selltobacco to minors. Though he had a below-average 2008, going 7-7 with a 5.15 ERA, he has had a great 2009 season thus far. Unlike other Madoff-related cases the suit does not containa securities claim, meaning plaintiffs can receive relevantinformation about the case before any trial which could bring tolight previously unknown details on the case. (Reporting by Lisa Richwine; Editing by Derek Caney) Stocks Regulatory News Global Markets. Why?The greatest rivalry in college basketball history One of the best rivalries in all of sports. The face of America’s video game industry for the last twenty.John Madden’s impact on the world of sport as well as the American culture as a whole is something that nobody on this list could even imagine mirroring.The fact that he is a big guy is just icing on the cake (pun intended.)Grandparents to young children, nearly every American male has had some form of Madden experience That says a lot.

forces crippled in offensives last year.Yet despite his non-sectarian message, the secularist Allawi did not rule out an alliance with the ultra-sectarian ISCI.(Additional reporting by Khalid al-Ansary; Editing by Samia Nakhoul) World. 201/ / Copyright Business Wire 2009. Roenicke was sent back to Louisville and Drew Sutton was recalled to give the club more depth on the bench.Alex Gonzalez, who had arthroscopic surgery on his right elbow June 22nd, has been sent to Louisville on a rehab assignment. You know that at least one person’s in your corner.He is NOT one of the best things about B/R. Green Bay Packers (9-7)- Aaron Rodgers was a top 10 QB on a sub par team last year Imagine what he will look like on a a good team.

It sounds nice for the Rockets, but it would never happen.So Camby could be a very solid addition to the Rockets, but a deal would be difficult to come by.If I had my choice, DeAndre Jordan would be the guy to go after. It’s the feeling that this could be the year the 49ers break through back into the stardom of the 80s and early 90s. ) The New York Jets will have the same chance just as any other team.Team That Made the Playoffs(*)AFC East: Twice A YearNew England (Week 2 and 11) Miami  (Week 5 and 8)* Buffalo (Week 6 and 13)AFC South: Houston (Week 1)Tennessee (Week 3)*Jacksonville (Week 10) Indianapolis ( Week 16)*NFC South: New Orleans ( Weeks 4)Carolina ( Week 11)*Tampa Bay ( Week 13)Atlanta ( Week 15)*AFC West:Oakland ( Week 7)AFC North:Cincinnati ( Week 17)The New York Jets have a hard schedule this year, but if their defense can work with their offense then their won’t be anything in their way from making it to the playoffs this year.The big question still at the QB and their WR positions. Factors thatcould cause or contribute to such differences include but are not limited todelays in completing the proposed acquisition, failures of closing conditions tobe satisfied and difficulties in integrating the operations and products of WindRiver and Tilcon. Can the Hawks find their “Lebron James”?I was thinking about this very question the other night when the Cavaliers had just finished their sweep of the Atlanta Hawks.

This has allowed for financing of the CIPand ongoing operations with only moderate historical annual rate increases, andthis is expected to continue through at least fiscal 2012. AMAHouston is currently Chapter of the Year and has won this national award threetimes in five years. FRANKFURT, March 1 (Reuters) – Germany’s DekaBankDSUGUD.UL has launched an investigation into its own internalbusiness procedures in order to determine if any mistakes inits trading activities had been made, a bank spokesman toldReuters late Sunday. The Packers brought in a new defensive coordinator, Dom Capers, switched to a 3-4 scheme and needed Thompson to help out, and he did.Overall, Thompson made some good decisions in this year’s draft, hopefully helping the Packers improve on that 6-10 record that landed them the No. [N.] * OPEC supply fell in February, according to a Reuterssurvey. Sme, page 8 RAILWAYS AID Transport Minister Lubomir Vazny aims to provide a 70million euro aid for Slovak Railways, which suffer from drop incontract volumes of country’s rail freight company ZSSK Cargo. He wins the three championships 3 years earlier, gets bored because it’s no longer hard to win (really, really bored) and then retires, only he decides to play football instead and Da Bears win two  Super Bowls in the early 90s with Jim Harbaugh at QB and MJ at Receiver).2.

“The Fourth Kind” isn’t the kind that Nome, Alaska, wants around.

It says something about the popularity of “Dancing With the Stars” that the show’s dancers have become almost as famous as the celebrities they’re paired with. Take Mark Ballas, who last season waltzed and tangoed his way to a first-place finish with Olympic gymnast Shawn Johnson.

If coming back after one season is going to bring familiarity of the system to the team, then future years will be golden.Tom Cable is what should be classified as a “Yes-man with a twist” He drafted Al Davis’ prototype players He has regular meetings with the boss. Thoughts:On some weeks Chris Volstad is likely to be listed among the 3-star options. His luck should turn around and no longer will he limbo the Mendoza Line. Look for the giants to run out of allot of tight formations during the year, and for Kevin Boss to take advantage of the middle of the field.The absence of Burress should help Boss in becoming a popular candidate for Manning.

One of his more impressive performances last season was on the road against Green Bay at Lambeau Field.  In single-digit temperatures, he went 28 of 42 for a season-high 414 yards with 2 TDs, 1 INT and the Texans defeated the Packers, 24-21 despite 4 turnovers.  He was also quite the Fantasy Football stud that day amassing over 20 points in most leagues on the frozen tundra of Lambeau. Believe it or not but last year, the Texans had the #3 overall, the #4 passing, the #13 rushing offense in the NFL!  Unfortunately, they were only the #17 scoring offense in the league.  That’s pretty impressive but, Matt Schaub must start all 16 games this season so that the offense doesn’t miss a beat. If Gore and this running back crew can stay healthy, they are supremely talented and versatile enough to help the quarterback and relatively inexperienced wide receiver group stay in ball games. – 9:30 a.m.–KTXL-TV (FOX), Sacramento/Stockton/Modesto, CA, 6:30 a.m – 7 a.m.–WWL-TV (CBS), New Orleans, LA, 7:30 a.m – 8:00 a.m.–WTWC-TV (NBC), Tallahassee, FL, 10 a.m. Guidance has tightened to mid-swaps plus 80 basis pointsfrom an initial mid-swaps plus 80 to 85 basis points, said IFRMarkets, a Thomson Reuters online news and market analysisservice. Guys like Bruce Smith became so highly valued in large part due to Deacon Jones’s accomplishments.There is one final reason why Jones appears on this list: The man is so nasty that I don’t want him coming after me.. 129.With this single-elimination tournament, anything can happen, and the unexpected happens. My heart beat at double time from South Carolina to Fort Myers.

With players like Hrbaty (4-9) and Johansson (5-9) it was harder to understand. Several former Soviet bloc countries have an excess of AAUs after their heavy industries collapsed in the 1990s, and are offering to sell them to those nations well above their Kyoto targets, including Japan. Treasury bailout program is nearly certain to fail, triggering a sense of personal despair Crisis in Credit  |  EconomyU.S. Hand the team over to Tyler Thigpen in 2009 and see what he does.

Oprah Winfrey made it official Friday morning: She will end “The Oprah Winfrey Show” in 2011.

Although Marie Osmond knew her son had problems, she had visited him often in Los Angeles, where he attended school at the Fashion Institute of Design and Merchandising, and thought he was doing better, a friend tells PEOPLE.

As a result, weare able to benefit from leading edge research while employing significantlyless capital than conventional organizations For additional information, please call Ms Briana L. Erickson toll-free at1-800-213-0689 or visit: To receive future press releases via email, please visit: http:// view the full HTML text of this release, please visit: http:// Notice Regarding Forward-Looking StatementsNo statement herein should be considered an offer or a solicitation of an offerfor the purchase or sale of any securities. Unique to ourbusiness model is the use of established research infrastructure owned by thevarious institutions we deal with, saving us significant capital which wouldotherwise be required for such costs as land and building acquisition, equipmentand capital equipment purchases, and other start up expenses. These solar coatings are less than 1/10th the thickness of `thin`films and make use of the world`s smallest functional solar cells, shown tosuccessfully produce electricity in a recently published peer-reviewed study inthe Journal of Renewable and Sustainable Energy of the American Institute ofPhysics.Through established relationships with universities, research institutions, andcommercial partners, we strive to identify technologies and businessopportunities on the leading edge of renewable energy innovation. An estimated 250 million registeredvehicles drive more than 6 billion miles on America`s roadways, every day; and * SolarWindow technologies which enable transparent glass windows to generateelectricity by coating their glass surfaces with the world`s smallest knownsolar cells.

About New Energy Technologies, Inc.New Energy Technologies, Inc., together with its wholly owned subsidiaries, is adeveloper of next generation alternative and renewable energy technologies.Among the Company`s technologies under development are:* MotionPower roadway systems for generating electricity by capturing thekinetic energy produced by moving vehicles. New Energy engineers have developed MotionPower technologies, designed togenerate `clean` electricity by harnessing the kinetic energy of the estimated250 million registered vehicles which drive more than 6 billion miles onAmerica`s roadways every day. New Energy also announced recently that the Company has filed nine new patentapplications with the United States Patent and Trademark Office (USPTO) in orderprotect novel features of its MotionPower technology for generating electricityfrom the kinetic energy of moving vehicles. Last month, the Company announced plans to expand its product range withdevelopment of a brand new fluid-driven MotionPower energy harvester for heavytrucks and vehicles, complimenting the Company`s newly-prototyped mechanicalMotionPower system for cars and light trucks. Once fully optimized for efficiency,engineers envision New Energy`s MotionPower device for cars and light truckscould be installed at high traffic locations such as toll booths, trafficintersections, rest areas, travel plazas, border crossings, neighborhoods withtraffic calming zones, and drive-thrus similar to the Burger King test site.

More than 150,000 cars drive through our Hillside store alone eachyear, and I think it would be great to capture the wasted kinetic energy ofthese hundreds of thousands of cars to generate clean electricity,” stated Mr.Paterno. Engineers have designed and built New Energy`s latest MotionPower prototype asan ultra-low profile, modular device which can be easily customized to varyinglengths based on site requirements. “It`s very exciting to be involved in the early testing and development of abrand new technology designed to generate electricity from the motion ofvehicles. Wallstein own and operate twelveBurger King restaurants in the New York Metro area.

The Company announced plans to initiate durability testing of its MotionPowerprototype device at quick-service giant, Burger King`s, prominent franchiserestaurant in the New York Metro area. Located in Hillside, New Jersey, theBurger King outlet is owned and operated by entrepreneurs, Mr Andrew Paternoand Mr Michael Wallstein Mr Paterno and Mr. Patel, Esq., President and CEO of New EnergyTechnologies, Inc. “I`m proud to announce that our engineering team has successfully completed ournewest, ultra-low profile, modular, second-generation MotionPower prototype.We`re eager to field test the device in a real world setting as part of ourongoing efforts to aggressively engineer, test, refine, and ultimately,commercially launch America`s first active roadway energy capture system of itskind,” explained Mr Meetesh V. Newest MotionPower energy harvester prototype completed; Prototype to undergoimportant field tests at drive-thru at prominent Burger King franchise in theNew York metropolitan area. BURTONSVILLE, Md.–(Business Wire)–New Energy Technologies, Inc. (Symbol: NENE), a next-generation alternative andrenewable energy developer, today announced that engineers have completeddevelopment of the Company`s newest MotionPower prototype for generatingelectricity from the movement of cars and light trucks, and will now undertakeactive field tests of the device at a drive-thru located at a prominent BurgerKing franchise in the New York metropolitan area.

Wrestlemania.” He believes he truly outshines everyone on the grandest stage of all.He can make that claim that he’s the main event at Wrestlemania. With only two wins on his record with nine losses, it would be kind of hard for the average fan to call Shawn “Mr Wrestlemania.”Despite his Mania record, Shawn is “Mr. Wrestlemania.” He may have lost majority of his Mania matches but he has also brought out the very best an opponent can dish out. Shawn won’t beat himself, you have to take him out and make sure he’s no longer breathing before you defeat him.Kurt Angle, Triple H, Chris Benoit, Bret Hart, Stone Cold, John Cena, Diesel, it took every bit of strength to battle it out with Shawn Michaels at Wrestlemania. Add me to that list that had to take him on.Never is there a competitor that is so hard to pin. Anyone who has kicked out of my tombstone deserves all the respect in the world That’s why I consider him “Mr. Mania.”Only difference between Shawn and myself at Mania besides my undefeated streak is simple Shawn Michaels is “Mr.

Wrestlemania.” BUT I AM WRESTLEMANIA!!!!That’s what Shawn is trying to capture that I hold rightfully in my possession He wants to be known as “WRESTLEMANIA” himself. Damn, this man has such a huge ego.I will not allow you Shawn to come out on top”Hole is finally dug out six feet deep.”Many say that it’s hard to beat a person a second time around Those who say that are right. This match will be the hardest task I will probably ever fight Beating Shawn once was hard enough. Beating him a second will be close to unthinkable.But there is something else on the line that has juiced me up more than ever in my entire career. Shawn is trying to make history as being the first to end the streak so he can be consider the greatest of all-time.

I want to be the man that ends the career of the greatest of all-time.Winning at Mania is more than just ending HBK’s career. This is finally showing that you don’t EVER doubt the wrath of the deadman I have laid careers to rest before. Shawn must now feel my wrath.”Jumps inside of the six-foot dugged out hole”The streak was never something I really had in mine during my first decade in this business. It wasn’t until till Wrestlemania 18, when I defeated the Nature Boy Ric Flair that the streak officially took toll on my career.Still till this day, I consider my streak as “the” streak.

As much as I love to sulk in the fact that I never been defeated at Wrestlemania, it’s still just another accolade to add to my hall of fame resume.I would love nothing more than to end my career undefeated at Mania That would be a huge sendoff to my career. With the exception of Brett Favre, all streaks are meant to be broken.This is not me doubting my abilities to beat Shawn Michaels at this year’s Wrestlemania. This is just a realization that this streak is in jeopardy and will always take a huge toll on my status and career until someone finally breaks it.I’ve heard so many people talking about the different superstars that can end my streak to better their careers. YEAH THAT’S FUNNY!Lays a casket inside of the six-foot hole.No superstar in this business is deserving to end this streak. Majority of the superstars don’t even deserve to take a crack at this streak. No matter how much it may help elevate that superstar, I’m not going to lie down to any wrestler. And there are a very few in the locker room who are capable of ending the streak.If my streak is going to come to an end, it needs to end in the right hands.

Ric Flair made sure if he was force to retire, he was going to retire to the right person at the right point of his career He chose Shawn Michaels. Flair knew Shawn would deliver the way he wanted to go out.Batista, John Cena, Triple H, Randy Orton, Edge, even CM Punk. These are the only superstars who I believe are capable of ending the streak and I would even allow to compete with me. That’s because I know they have a shot.And if everyone really want to talk, Kane is more deserving of a shot to end the streak more than anyone. Other than Shawn Michaels.Pours lighter fluid all over the casket that was set inside the hole.I’ve asked myself over the last four or five years the same question.

ENGLEWOOD, Colo.–(Business Wire)–Liberty Global, Inc. Excluding the severance charges, net earnings for the second quarter wereapproximately $0.5 million or $0.03 per diluted share.Second quarter revenue decreased 25.5% (or 20.9% on a constant currency basis)to $215.4 million compared to revenue of $289.2 million in the prior-yearquarter.A quarterly cash dividend of $0.13 per share will be paid on August 27, 2009to all shareholders of record as of August 13, 2009.”We were somewhat encouraged by revenue trends during the second quarter whichindicate that our business could be emerging from the trough that we saw inthe previous two quarters,” said President and CEO, Roger H Ballou. On a total-company basis,these assumptions correspond to a range for 2009 controllable operating expensesof $7.3 billion to $7.4 billion. To learn more about IPA, visit Now in its 10th year, the TMC Labs Innovation Awards honor products that havedemonstrated raw innovation, unique features, and significant contributionstoward improving communications technology. “I wish all problems were this easy to fix.”"We should be engineering this problem out of existence,” he added.Smith and his colleagues analyzed causes of childhood bathtub- and shower-related injuries treated in US emergency rooms from 1990-2007. Sme, page 6 VOLKSWAGEN UP! REPLACES SKODA OCTAVIA Volkswagen Slovakia, unit of Germany’s car group Volkswagen(VOWG.DE), said production of the new small-size family modelUp! will replace production of Skoda Octavia Up! is expected togo on-line from the beginning of 2011. The companyproudly employs 26,000 associates in more than 60 locations nationwide who arepoised to serve customers beyond their expectations.

EDEN PRAIRIE, MN, Aug 13 (MARKET WIRE) — Compellent Technologies, Inc. For more information on the Company or itsprojects, please visit Statement Regarding Forward-Looking StatementsThis release contains “forward-looking” statements that are made pursuantto the Safe Harbor provisions of the Private Securities Litigation ReformAct of 1995. NEW YORK–(Business Wire)–L-3 Communications (NYSE: LLL) announced today that its Systems Field Support(SFS) division was awarded a 60-day base contract with eight option years fromthe U.S. Koeltl reviewed 37 separate alleged wrongful statements andconcluded that Cummins was not defamed, and that he failed toshow the defendants acted negligently. COLDHARBOUR, England (Reuters Life!) – The affluent English county of Surrey — with its rolling hills, historic tiled houses and ancient oak woodlands to the south of London — may not seem the most obvious place to prospect for oil.

Weare progressing well with the integration, with most of the administrativefunctions fully operational under the Noah umbrella. Capital expenditures inthe first half of 2009 totaled $3.2 million, compared with $17.7 million inthe same period of 2008.Total shareholders’ equity rose to $168.1 million at June 30, 2009, from$157.5 million at March 31, 2009.Recent DevelopmentOn August 21, 2009, the Company adopted shareholder resolutions at itsannual general meeting held in Shenyang City, China. What if there aren’t 5 billion barrels?” For complete coverage of Brazil’s plans to overhaul its oil legislation, please click on [ID:nN3112244] (Reporting by Raymond Colitt, Fernando Exman, and Natuza Nery; Editing by Marguerita Choy) Brazil Brazil. Herrell also held marketing management positions with ROLM and IBM, and earned a B.A.

For more information, visit, email or call toll free 1.866.472.6764.SOURCEXiotech CorporationJason Sprenger of Xiotech Corporation, +1-952-983-3110,. This workquickly identified several targets and has led to the delineation of a NI43-101 Measured & Indicated Mineral Resource of 461 million tonnesgrading 0.27g/t gold (3.9Moz), 11g/t silver (163Moz) and 0.11% copper(1.09Blb) and an Inferred Mineral Resource of 166 million tonnes grading0.11g/t gold (0.6Moz), 7 g/t silver (39Moz) and 0.10% copper (0.36Blb).Within the overall deposit, there is a ‘gold domain zone’ containingMeasured & Indicated Mineral Resource of 209 million tonnes grading0.48g/t gold (3.2Moz) and 11g/t silver (71Moz) and within this zone,there is a relatively higher grade gold resource defined at surface. 3 /PRNewswire-USNewswire/ — Andrew Taylor, Chairman and CEOof Enterprise Holdings, will discuss the building out of advanced energyinfrastructure at the National Energy Summit & International Dialogue,September 23, in Washington, DC.Taylor will take part in a leadership dialogue moderated by Newsweek’sNational Economic Correspondent Michael Hirsh entitled, “Clearing Obstacles toa National Transmission Superhighway.” The panel will include: Dr. NEW YORK, Sept 8 (Reuters) – U.S. KJVG, formed as apartnership between KBR E&C Australia Pty Ltd, JGC Corporation, Clough ProjectsAustralia Pty Ltd and Hatch Associates Pty Ltd Group, completed the updatedonshore facilities Front End Engineering and Design (FEED) and executionplanning earlier this year.

David Bianculli says that Conan O’Brien has struck a blow for the “Tonight Show” — and himself.

Traits Marketing Lead, said the name Genuity isdesigned to communicate Monsanto’s commitment to innovation and farmersuccess. Tight credit conditions have hit automobile sales heavilyin urban areas, where most vehicle sales require some sort offinancing The reliance on loans is lower in rural areas (Reporting by Janaki Krishnan) Japan. is a national provider of specialty pharmacy and diseasemanagement services focused on HIV/AIDS patients as well as specializedbiopharmaceutical medications and services to chronically ill patients. Cleveland State plays a highly motivated Arizona this Sunday. Regardless of whether you enjoy the WBC or not, and I admit it has grown on me somewhat, you need to understand one basic fact.The results are basically meaningless.That’s right. sales sank almost 19 percent in the first two months of the year in a market down by 39 percent over the same period.VW’s U.S.

ROY, Utah–(Business Wire)–UpLiftNutrition, Inc. Results for these holes areexpected to be announced in early April. Alternatively, by combining with Kria, which has sufficient funds on handto finance planned activities in 2009, Beartooth Shareholders, throughtheir ownership of New Kria Shares, will continue to participate in anyincrease in the value of Kria’s projects, as well as the current assetsof Beartooth. This game has much more riding on it as an Irish loss will continue to dig the proverbial fork further into South Bend’s Best.My pick: UConn 85, Notre Dame 76 (13) Clemson at (25) Florida State, 2:00 Saturday on ESPN360Both of these teams are slowly heading south in the ACC, but only Clemson, not Florida State, is safely in the field of 65. For more information please visit thecompany website at http:// .Safe Harbor StatementThis press release contains certain statements that may include “forwardlooking statements.” All statements other than statements of historical factincluded herein are “forward-looking statements.” These forward lookingstatements are often identified by the use of forward-looking terminology suchas “believes,” “expects” or similar expressions, involve known and unknownrisks and uncertainties. “It signals a new era of sociallyintertwined games where the distinction between the producer and player arecompletely blurred.”"We’re thrilled to have been picked as a winner,” said BernhardAufreiter, Upper Austria University. I’m saying that there’s the possibility.  Steroids are not a new issue.

From Kevin Kernan:”Teixeira’s a great player, there’s no question about that and I appreciate the way he plays and I think the Yankee fans are going to enjoy him,” Donnie Baseball said. Salesof ADDERALL XR are expected to decrease significantly due to genericcompetition that is anticipated to commence on April 1, 2009. Essentially without a first-round pick now, I grasped at Matt Cassel off the waiver wire. Might as well see what I can do as a spoiler, right? Cassel did little for my hopes at the start of the season, but who knew he would finish so strong? With Cassel at QB and the surprise RB duo of Matt Forte and Pierre Thomas (Mewelde Moore helped in those Willie Parkerless weeks), The EvilMonkeys pulled out a Wild Card spot and eventual championship.I had survived the drafting of Tom Brady. Case Study No. He’s targeted often, and the Pats linebackers are getting older every week. New York Giants at Dallas Who to Start: Derrick Ward, Domenick Hixon, Amani Toomer, Kevin Boss, Eli Manning, Marion Barber, Tashard Choice Who to Sit: Roy Williams, Brandon Jacobs, Ahmad Bradshaw What to Expect: I never like it when there is discontent that can disrupt an offense, and that’s what we have here. When guys are going to the offensive coordinator for a closed-door meeting because they don’t like the offense, I think that’s an issue. For more information, please visit http:// * 80 PLUS is a program administered by ECOS; an organization committed toimproving the environment.

His story is one of talent, commitment and passion which has seen him grow into a world-class player. Fortunately for Schottenheimer, the Rams aren’t really good at stopping either.With the Rams ranking 26th against the run, it’s time for Schottenheimer to take some strain off Old Faithful’s arm, and see what Thomas Jones can do with 20 carries a game.Since the Raiders’ game, Jones has been running like a man possessed. Previously, she was the mediarelations coordinator at the Indiana Bar Foundation. Louis to take on the Rams.  Regardless of that outcome, the game that inevitably will decide the 49ers’ season will be in Week 10 onMonday Night Football in Arizona.  The 3-5 49ers will take on either the 5-3 Cardinals, or the 4-4 Cardinals. Either way it will be a must-win for the 49ers.  And if they win, even though it will be only two wins so far in the Singletary era, it will have the 49ers right back in either at tie for first, or one game out of the top spot in the anemic NFC West. .

Customarily considered a disease of adults, T2DM isincreasingly being diagnosed in children in correlation to increasing juvenileobesity rates.About NaturloseSpherix holds patents on the use of Naturlose as a drug to treat diabetes. As T2DMprevalence rates doubled between 1990 and 2005, the CDC characterized theincrease as an epidemic. There are an estimated 23.6 million people in the U.S.(7.8% of the population) with diabetes, and 17.9 million cases have beendiagnosed.Of the diagnosed diabetes cases, 90% are type 2. While T2DM is often initially managed by increasing exercise inconjunction with dietary modification, medications are usually needed as thedisease progresses. Diabetes Obesity Metab1999 I 5 285-291)A dose and time-of-administration study was conducted to verify the dosingplan to be used in the phase 3 trial. (Donner TW, WilberJF, Ostrowski D.D-Tagatose, a novel hexose: Acute effects on carbohydratetolerance in subjects with and without type 2 diabetes.

The results suggest that, in addition to minimizing the extent ofatherosclerosis from carbohydrate consumption, a diet enriched in tagatose mayfavor a more stable plaque phenotype less likely to cause stroke or myocardialinfarction.Prior Clinical Trials with NaturloseEight healthy individuals and eight individuals with type 2 diabetes underwentseparate 3-hour oral glucose and tagatose tolerance tests.The subjects werealso given 75 g of tagatose followed 30 minutes later by 75 g of glucose.Between test days, participants received 10 g of tagatose per day.Ingestionof the tagatose load (75 g) caused no increase in plasma insulin or glucoseconcentrations in either healthy or diabetic individuals. A novel findingin this study was that atherosclerotic lesions detected in TAG-fed mice werecomposed of increased collagen, indicative of a more stable plaque phenotype. Patients were required to pass specific inclusion criteria at screening and atbaseline, including an HbA1c level at screening and baseline between 6.6% and9.0%.The baseline visit followed an 8-week run-in period in which patientswere instructed to follow a weight-maintaining diet and a daily exerciseprogram under the supervision of the investigator.The run-in period wasdesigned to compensate for the effect of diet and exercise on the estimatedeffectiveness of the drug.The treatment duration was six months and 38patients have been randomized to one of the three doses to date. Naturlose was administeredorally with meals (TID) at three different doses, 2.5, 5.0, and 7.5 g. The LDL:HDL ratio was improved for two ofthe three dose groups by an average of 0.3.”The results of this ongoing Phase 2 study are encouraging and reaffirm ourbelief that Naturlose may be a valuable treatment option for patients withType 2 diabetes,” said Dr.

Naturlose appears to begin showing an effect on HbA1c within the range ofdoses selected for this minimum-dose study.The ongoing Phase 3double-blinded study of efficacy is being conducted at a 15 g dose (TID), andis powered to detect a 0.5% reduction in HbA1c.Over the course of the Phase 2 trial, Naturlose also decreased the averageserum triglycerides of the patients by -59 mg/dl by the end of the first monthon therapy, a decrease from baseline that remained at -41 mg/dl by the end ofthe 6 months of the trial.Naturlose also decreased serum LDL by an average-13 mg/dl by the end of the first month on therapy, while serum HDL wasessentially unchanged (+0.9 mg/dl). The comparator is the 2.5 g dose.The primary endpoint forthe study is reduction in HbA1c after 6 months on the drug.After 6 months ondrug, the patients in the 7.5 g group experienced an average reduction of 0.3%in HbA1c from the HbA1c of the 2.5 g group.At that same 6-month point, the5.0 g group averaged a reduction in HbA1c of 0.05% from the 2.5 g group. The Phase 2 trial is expected to be completed in early 2010.In the ongoing single-blind study designed to establish the minimum dose ofNaturlose capable of causing a beneficial effect, Naturlose is administeredorally with meals, three times daily (TID) at three different doses:2.5,5.0, and 7.5 g. Preliminary Data Demonstrates Reduction of HbA1c Levels With Doses an Order ofMagnitude Lower than the Dose Used in the Current Phase 3 Trial.BETHESDA, Md., June 24 /PRNewswire-FirstCall/ — Spherix Incorporated (NasdaqCM: SPEX), an innovator in biotechnology for diabetes therapy, and a providerof technical and regulatory consulting services to food, supplement,biotechnology and pharmaceutical companies, today announced positivepreliminary results from a Phase 2 clinical trial of its novel compound,Naturlose(R) (D-tagatose), in the treatment and management of Type 2 diabetes.

Whether shows are serious or silly, the mood changes when the boozy grandmother enters the scene.

An Ohio police chief accused of stealing from the surrogate who carried Sarah Jessica Parker’s twins was found guilty.

Susan Boyle has gone shopping for a birthday present — for herself.


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